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p73: A Multifunctional Protein in Neurobiology

8 Mar 2011

Abstract excerpt

p73, a transcription factor of the p53 family, plays a key role in many biological processes including neuronal development. Indeed, mice deficient for both TAp73 and ΔNp73 isoforms display neuronal pathologies, including hydrocephalus and hippocampal dysgenesis, with defects in the CA1-CA3 pyramidal cell layers and the dentate gyrus. TAp73 expression increases in parallel with neuronal differentiation and its...

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PMID: 21380933
DOI: 10.1007/s12035-011-8172-6

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