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Article

OPA1 promotes ferroptosis by augmenting mitochondrial ROS and suppressing an integrated stress response.

Molecular cell - 22 Aug 2024

Liang Felix G, Zandkarimi Fereshteh, Lee Jaehoon, Axelrod Joshua L, Pekson Ryan, Yoon Yisang, Stockwell Brent R, Kitsis Richard N

Abstract excerpt

Ferroptosis, an iron-dependent form of nonapoptotic cell death mediated by lipid peroxidation, has been implicated in the pathogenesis of multiple diseases. Subcellular organelles play pivotal roles in the regulation of ferroptosis, but the mechanisms underlying the contributions of the mitochondria remain poorly defined. Optic atrophy 1 (OPA1) is a mitochondrial dynamin-like GTPase that controls mitochondrial...

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Source

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Identifiers

PMID: 39142278
DOI: 10.1016/j.molcel.2024.07.020
PMCID: PMC11373561

Genes

OPA1
ATF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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