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Article

Mitochondrial retention of Opa1 is required for mouse embryogenesis.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Aug 2010

Moore Billie A, Gonzalez Aviles Gladys D, Larkins Christine E, Hillman Michael J, Caspary Tamara

Abstract excerpt

Mitochondria are dynamic cellular organelles that balance fission and fusion to regulate organelle morphology, distribution, and activity, and Opa1 is one of three GTPases known to regulate mitochondrial fusion. In humans, loss of a single Opa1 allele causes dominant optic atrophy, a degenerative condition that leads to loss of vision. Here we demonstrate that the lilR3 mutant mouse phenotype is due to a point...

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Share to Mice, Inbred C3H
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20652258
DOI: 10.1007/s00335-010-9272-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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