Article
TAp73 knockout shows genomic instability with infertility and tumor suppressor functions.
Genes & development - 1 Oct 2008
Tomasini Richard, Tsuchihara Katsuya, Wilhelm Margareta, Fujitani Masashi, Rufini Alessandro, Cheung Carol C, Khan Fatima, Itie-Youten Annick, Wakeham Andrew, Tsao Ming-Sound, Iovanna Juan L, Squire Jeremy, Jurisica Igor, Kaplan David, Melino Gerry, Jurisicova Andrea, Mak Tak W
Abstract excerpt
The Trp53 gene family member Trp73 encodes two major groups of protein isoforms, TAp73 and DeltaNp73, with opposing pro- and anti-apoptotic functions; consequently, their relative ratio regulates cell fate. However, the precise roles of p73 isoforms in cellular events such as tumor initiation, embryonic development, and cell death remain unclear. To determine which aspects of p73 function are attributable to the...
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