Article

Inference of phenotype-relevant transcriptional regulatory networks elucidates cancer type-specific regulatory mechanisms in a pan-cancer study

2018-08-10

Abstract excerpt

<h4>ABSTRACT</h4> Reconstruction of transcriptional regulatory networks (TRNs) is a powerful approach to unravel the gene expression programs involved in healthy and disease states of a cell. However, these networks are usually reconstructed independent of the phenotypic properties of the samples and therefore cannot identify regulatory mechanisms that are related to a phenotypic outcome of interest. In this stud...

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Literature Corpus work: d7976471-66b4-564f-b6f4-ace61f01bdac
DOI: 10.1101/389734

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