Characterizing the targets of transcription regulators by aggregating ChIP-seq and perturbation expression data sets

Abstract excerpt

Mapping the gene targets of chromatin-associated transcription regulators (TRs) is a major goal of genomics research. ChIP-seq of TRs and experiments that perturb a TR and measure the differential abundance of gene transcripts are a primary means by which direct relationships are tested on a genomic scale. It has been reported that there is poor overlap in the evidence across gene regulation strategies, emphasizin...

Topics

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• Gene Knockout Techniques
• Gene Regulatory Networks
• MicroRNAs
• Mouse Embryonic Stem Cells
• Protein Interaction Maps
• Ribonuclease III
• RNA-Seq
• Single-Cell Analysis

Identifiers and source

Literature Corpus work

9ff95cbc-1107-5b79-8d92-145b5e2ebee2

DOI

10.1101/2022.08.30.505909