Article

Perturbation-response genes reveal signaling footprints in cancer gene expression

2016-07-25

Abstract excerpt

Aberrant cell signaling is known to cause cancer and many other diseases, as well as a focus of treatment. A common approach is to infer its activity on the level of pathways using gene expression. However, mapping gene expression to pathway components disregards the effect of post-translational modifications, and downstream signatures represent very specific experimental conditions. Here we present PROGENy, a met...

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Literature Corpus work: 23404271-64a1-5600-a795-95715f1c7797
DOI: 10.1101/065672

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