Article

CAMK2-NR4A1 signaling initiates metabolic substrate switching to induce heart failure with reduced ejection fraction

2025-10-16

Abstract excerpt

Heart failure with reduced ejection fraction (HFrEF) is marked by a shift in cardiac energy metabolism from fatty acid oxidation to glucose utilization. This “fuel switch” promotes accumulation of glucose byproducts that modify calcium-handling proteins and impair cardiac function, yet the initiating signals remain unclear. We identify Ca 2+ /calmodulin-dependent protein kinase II (CAMK2) as an upstream regulator...

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Literature Corpus work: 542f02c6-af83-5d14-9092-fc5964d9fbec
DOI: 10.1101/2025.10.16.682731

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