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AOP report: Development of an adverse outcome pathway for oxidative DNA damage leading to mutations and chromosomal aberrations.

Environmental and molecular mutagenesis - 1 Mar 2022

Cho Eunnara, Allemang Ashley, Audebert Marc, Chauhan Vinita, Dertinger Stephen, Hendriks Giel, Luijten Mirjam, Marchetti Francesco, Minocherhomji Sheroy, Pfuhler Stefan, Roberts Daniel J, Trenz Kristina, Yauk Carole L

Abstract excerpt

The Genetic Toxicology Technical Committee (GTTC) of the Health and Environmental Sciences Institute (HESI) is developing adverse outcome pathways (AOPs) that describe modes of action leading to potentially heritable genomic damage. The goal was to enhance the use of mechanistic information in genotoxicity assessment by building empirical support for the relationships between relevant molecular initiating events...

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Identifiers

PMID: 35315142
DOI: 10.1002/em.22479
PMCID: PMC9322445

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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