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Article

Increased lifespan in transgenic Caenorhabditis elegans overexpressing human alpha-synuclein.

Experimental gerontology - 1 Sept 2006

Vartiainen Suvi, Aarnio Vuokko, Lakso Merja, Wong Garry

Abstract excerpt

alpha-Synuclein is a short 14-kDa protein found in pathological lesions of age-related neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, and multiple system atrophy. Its overexpression in transgenic mice, rats, Drosophila melanogaster, and Caenorhabditis elegans recapitulates many of the pathologic features observed in human Parkinson's disease including loss of dopaminergic neurons...

Topics

Aging
Animals
Animals, Genetically Modified
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Gene Expression Regulation
Longevity
Mutation
Ovum
Pharynx
Receptor, Insulin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Transgenes

alpha-Synuclein

Source

Identifiers

PMID: 16782295
DOI: 10.1016/j.exger.2006.05.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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