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MAPK14/p38α shapes the molecular landscape of endometrial cancer and promotes tumorigenic characteristics

20 Dec 2024

Abstract excerpt

The molecular underpinnings of high-grade endometrial carcinoma (HGEC) metastatic growth and survival are poorly understood. Here, we show that ascites-derived and primary tumor HGEC cell lines in 3D spheroid culture faithfully recapitulate key features of malignant peritoneal effusion and exhibit fundamentally distinct transcriptomic, proteomic, and metabolomic landscapes compared with conventional 2D...

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PMID: 39708320
DOI: 10.1016/j.celrep.2024.115104

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