Article

A U1–U3 snRNA–snoRNA interaction couples SF3B1 mutation to chromatin-state rewiring and genome instability

2026-06-08

Abstract excerpt

Mutations in spliceosome factors such as SF3B1 are recurrent across human diseases, including myelodysplastic syndromes and leukemia 1–4 , yet splicing defects alone do not fully explain the widespread chromatin alterations and genome instability in mutant cells 5 . Here, by comprehensively mapping snRNA-directed RNA–RNA interactions, we identify two previously unrecognized interaction motifs in U1 snRNA beyond...

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Literature Corpus work: e362e3ea-8dc6-5179-a889-5cfc83c06a2b
DOI: 10.64898/2026.06.06.722969

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