Article

A Unifying Mechanism for Shared Splicing Aberrations in Splicing Factor Mutant Cancers

2025-10-09

Abstract excerpt

Cancer-associated splicing factor (SF) mutations in SF3B1 , U2AF1 , and SRSF2 induce distinct changes in alternative splicing (AS). Yet these mutations are strikingly mutually exclusive, pointing to a convergent downstream mechanism. We hypothesized this would be reflected in the AS transcriptome. By analyzing transcriptomes of 395 patients with clonal myeloid disorders and 64 healthy donors, we found most AS a...

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Literature Corpus work: 042baf38-5b52-5b4c-a9d5-54c964ebd45a
DOI: 10.1101/2025.10.08.679601

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