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Alpha-synuclein: a pathological factor with Aβ and tau and biomarker in Alzheimer’s disease

31 Dec 2022

Abstract excerpt

BACKGROUND: Alpha-synuclein (α-syn) is considered the main pathophysiological protein component of Lewy bodies in synucleinopathies. α-Syn is an intrinsically disordered protein (IDP), and several types of structural conformations have been reported, depending on environmental factors. Since IDPs may have distinctive functions depending on their structures, α-syn can play different roles and interact with several...

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PMID: 36587215
DOI: 10.1186/s13195-022-01150-0

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