Article

Microfluidic deep mutational scanning of the human executioner caspases reveals differences in structure and regulation

2021-06-08

Abstract excerpt

The human caspase family comprises 12 cysteine proteases that are centrally involved in cell death and inflammation responses. The members of this family have conserved sequences and structures, highly similar enzymatic activities and substrate preferences, and overlapping physiological roles. In this paper, we present a deep mutational scan of the executioner caspases CASP3 and CASP7 to dissect differences in the...

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Literature Corpus work: e22f2646-0102-509e-bba5-6429eb89eb66
DOI: 10.1101/2021.06.08.447609

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