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Article

Novel small molecule inhibitors of caspase-3 block cellular and biochemical features of apoptosis.

The Journal of pharmacology and experimental therapeutics - 1 Jan 2003

Scott Clay W, Sobotka-Briner Cindy, Wilkins Deidre E, Jacobs Robert T, Folmer James J, Frazee William J, Bhat Ratan V, Ghanekar Smita V, Aharony David

Abstract excerpt

Caspase-3 is an intracellular cysteine protease, activated as part of the apoptotic response to cell injury. Its interest as a therapeutic target has led many to pursue the development of inhibitors. To date, only one series of nonpeptidic inhibitors have been described, and these have limited selectivity within the caspase family. Here we report the properties of a series of anilinoquinazolines (AQZs) as potent...

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PMID: 12490620
DOI: 10.1124/jpet.102.039651

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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