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Article

Designed BH3 Peptides with High Affinity and Specificity for Targeting Mcl-1 in Cells

23 Jul 2014

Abstract excerpt

Mcl-1 is overexpressed in many cancers and can confer resistance to cell-death signaling in refractory disease. Molecules that specifically inhibit Mcl-1 hold potential for diagnosing and disrupting Mcl-1-dependent cell survival. We selected three peptides from a yeast-surface display library that showed moderate specificity and affinity for binding to Mcl-1 over Bfl-1, Bcl-xL, Bcl-2, and Bcl-w. Specificity for...

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PMID: 25052212
DOI: 10.1021/cb500340w

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