Article
Novel mutant green fluorescent protein protease substrates reveal the activation of specific caspases during apoptosis.
Chemistry & biology - 1 Jun 1999
Mahajan N P, Harrison-Shostak D C, Michaux J, Herman B
Abstract excerpt
BACKGROUND: The caspase-mediated proteolysis of many cellular proteins is a critical event during programmed cell death or apoptosis. It is important to determine which caspases are activated in mammalian cells, and where and when activation occurs, upon receipt of specific death stimuli. Such information would be useful in the design of strategies to regulate the activation of caspases during apoptosis. RESULTS:...
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