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Article

Designing an apoptosis reporter by mutagenesis-based insertion of caspase-3 cleavage motif into green fluorescence protein.

Journal of advanced research - 1 Apr 2026

Lee Dong Gil, Yang Hae-Jun, Chae Unbin, Lee Hong Jun, Lee Dong-Seok, Chung Kyung-Sook, Kwon Taeho, Kim Hakjin, Song In-Sung, Park Young-Ho, Kim Sun-Uk

Abstract excerpt

INTRODUCTION: Apoptosis is an essential process for organisms and animal development, and its dysregulation is related to the progression of several diseases. Therefore, methods to detect apoptosis are necessary for mechanistic research and drug development. To overcome the disadvantages of traditional methods for detecting apoptosis, a variety of imaging strategies based on enzyme-mediated fluorescence...

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Identifiers

PMID: 40571193
DOI: 10.1016/j.jare.2025.06.070
PMCID: PMC13000946

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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