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Article

The mitochondrial respiratory chain is essential for haematopoietic stem cell function.

Nature cell biology - 1 Jun 2017

Ansó Elena, Weinberg Samuel E, Diebold Lauren P, Thompson Benjamin J, Malinge Sébastien, Schumacker Paul T, Liu Xin, Zhang Yuannyu, Shao Zhen, Steadman Mya, Marsh Kelly M, Xu Jian, Crispino John D, Chandel Navdeep S

Abstract excerpt

Adult and fetal haematopoietic stem cells (HSCs) display a glycolytic phenotype, which is required for maintenance of stemness; however, whether mitochondrial respiration is required to maintain HSC function is not known. Here we report that loss of the mitochondrial complex III subunit Rieske iron-sulfur protein (RISP) in fetal mouse HSCs allows them to proliferate but impairs their differentiation, resulting in...

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Identifiers

PMID: 28504706
DOI: 10.1038/ncb3529
PMCID: PMC5474760

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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