Article

Redox imbalance dictates dependence on GOT1 versus GOT2 for rod photoreceptor health during aging and stress

2026-04-07

Abstract excerpt

Photoreceptor (PR) loss causes vision loss in many blinding diseases, and effective therapies to prevent this cell loss are lacking. Aspartate aminotransferases (GOTs), located in the cytosol (GOT1) and mitochondria (GOT2), are key components of the malate-aspartate shuttle, which transfers reducing equivalents from cytosol to mitochondria. Previous work has implicated the GOTs as potential modulators of blinding...

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Literature Corpus work: f26537ca-1080-5291-926a-22940ca21795
DOI: 10.64898/2026.04.05.716322

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