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Red blood cell metabolism in Down syndrome: hints on metabolic derangements in aging

21 Dec 2017

Abstract excerpt

Red blood cells (RBCs) are the most abundant cell in the human body. During their ∼120-day life span in the circulatory system, RBCs release oxygen to all human tissues while being exposed to tissue metabolic activity. Owing to the relative simplicity of their intrinsic metabolism and the abundance of metabolite transporters in RBC membranes, the metabolism of mature erythrocytes indirectly mirrors systemic...

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PMID: 29296929
DOI: 10.1182/bloodadvances.2017011957

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