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Data-driven clustering of prefrontal activation identifies functional phenotypes under prioritized dual-task walking conditions in Parkinson's disease.

Neuroscience letters - 1 Aug 2026

Zhang Xinyuan, Li Weihua, Hu Yankun, Yu Yang, Lu Jiewei, Liang Siquan, Han Jianda, Cheng Yuanyuan, Wu Jialing, Yu Ningbo

Abstract excerpt

BACKGROUND: Gait impairment in Parkinson's disease (PD) relates to motor-cognitive interactions, yet the specific neural characteristics patterns of different individuals under various task strategies remain unclear. This study aimed to explore prefrontal activation heterogeneity in three prioritized dual-task walking (DTW) conditions and to identify subgroups based on neural activation characteristics, thus...

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PMID: 42314968
DOI: 10.1016/j.neulet.2026.138663

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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