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Cyp33 Binds AU-Rich RNA Motifs via an Extended Interface that Competitively Disrupts the Gene Repressive Cyp33-MLL1 Interaction <i>in vitro</i>

2020-08-07

Abstract excerpt

Cyp33 is an essential human cyclophilin prolyl isomerase that plays myriad roles in splicing and chromatin remodeling. In addition to a canonical cyclophilin (Cyp) domain, Cyp33 contains an RNA-recognition motif (RRM) domain, and RNA-binding triggers proline isomerase activity. One prominent role for Cyp33 is through a direct interaction with the mixed lineage leukemia protein 1 (MLL1, also known as KMT2A) complex...

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Literature Corpus work
29153cd3-2992-50b6-8e5e-f0ba1c11e26b
DOI
10.1101/2020.08.07.241166
Open publication

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Cyp33 Binds AU-Rich RNA Motifs via an Extended Interface that Competitively Disrupts the Gene Repressive Cyp33-MLL1 Interaction <i>in vitro</i>DOI 10.1101/2020.08.07.241166
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