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Roles of Prolyl Isomerases in RNA-Mediated Gene Expression

18 May 2015

Abstract excerpt

The peptidyl-prolyl cis-trans isomerases (PPIases) that include immunophilins (cyclophilins and FKBPs) and parvulins (Pin1, Par14, Par17) participate in cell signaling, transcription, pre-mRNA processing and mRNA decay. The human genome encodes 19 cyclophilins, 18 FKBPs and three parvulins. Immunophilins are receptors for the immunosuppressive drugs cyclosporin A, FK506, and rapamycin that are used in organ...

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PMID: 25992900
DOI: 10.3390/biom5020974

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