Article
Synergic interplay of the La motif, RRM1 and the interdomain linker of LARP6 in the recognition of collagen mRNA expands the RNA binding repertoire of the La module.
Nucleic acids research - 1 Jan 2015
Martino Luigi, Pennell Simon, Kelly Geoff, Busi Baptiste, Brown Paul, Atkinson R Andrew, Salisbury Nicholas J H, Ooi Zi-Hao, See Kang-Wei, Smerdon Stephen J, Alfano Caterina, Bui Tam T T, Conte Maria R
Abstract excerpt
The La-related proteins (LARPs) form a diverse group of RNA-binding proteins characterized by the possession of a composite RNA binding unit, the La module. The La module comprises two domains, the La motif (LaM) and the RRM1, which together recognize and bind to a wide array of RNA substrates. Structural information regarding the La module is at present restricted to the prototypic La protein, which acts as an...
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