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In vivo Characterization of the Critical Interaction between the RNA Exosome and the Essential RNA Helicase Mtr4 in Saccharomyces cerevisiae

2022-11-01

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<h4>ABSTRACT</h4> The RNA exosome is a conserved molecular machine that processes/degrades numerous coding and non-coding RNAs. The 10-subunit complex is composed of three S1/KH cap subunits (human EXOSC2/3/1; yeast Rrp4/40/Csl4), a lower ring of six PH-like subunits (human EXOSC4/7/8/9/5/6; (yeast Rrp41/42/43/45/46/Mtr3), and a singular 3’-5’ exo/endonuclease DIS3/Rrp44. Recently, several disease-linked missense...

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Literature Corpus work: 84fecd93-a54e-5cc0-a6f7-d6976f56b89b
DOI: 10.1101/2022.10.31.514520

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<i>In vivo</i> Characterization of the Critical Interaction between the RNA Exosome and the Essential RNA Helicase Mtr4 in <i>Saccharomyces cerevisiae</i>

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