Article
Systemic GDF11 attenuates depression-like phenotype in aged mice via stimulation of neuronal autophagy.
Nature aging - 1 Feb 2023
Moigneu Carine, Abdellaoui Soumia, Ramos-Brossier Mariana, Pfaffenseller Bianca, Wollenhaupt-Aguiar Bianca, de Azevedo Cardoso Taiane, Camus Claire, Chiche Aurélie, Kuperwasser Nicolas, Azevedo da Silva Ricardo, Pedrotti Moreira Fernanda, Li Han, Oury Franck, Kapczinski Flávio, Lledo Pierre-Marie, Katsimpardi Lida
Abstract excerpt
Cognitive decline and mood disorders increase in frequency with age. Many efforts are focused on the identification of molecules and pathways to treat these conditions. Here, we demonstrate that systemic administration of growth differentiation factor 11 (GDF11) in aged mice improves memory and alleviates senescence and depression-like symptoms in a neurogenesis-independent manner. Mechanistically, GDF11 acts...
Topics
- Mice
- Animals
- Depression
- Depressive Disorder, Major
- Growth Differentiation Factors
- Phenotype
- Autophagy
- Mammals
- Bone Morphogenetic Proteins