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Orthotopic T-Cell Receptor Replacement—An “Enabler” for TCR-Based Therapies

1 Jun 2020

Abstract excerpt

Natural adaptive immunity co-evolved with pathogens over millions of years, and adoptive transfer of non-engineered T cells to fight infections or cancer so far exhibits an exceptionally safe and functional therapeutic profile in clinical trials. However, the personalized nature of therapies using virus-specific T cells, donor lymphocyte infusion, or tumor-infiltrating lymphocytes makes implementation in routine...

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PMID: 32492858
DOI: 10.3390/cells9061367

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