Evaluation of TCR Gene Editing Achieved by TALENs, CRISPR/Cas9, and megaTAL Nucleases.

doi:10.1038/mt.2015.197

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Article

Evaluation of TCR Gene Editing Achieved by TALENs, CRISPR/Cas9, and megaTAL Nucleases.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 Mar 2016

Osborn Mark J, Webber Beau R, Knipping Friederike, Lonetree Cara-lin, Tennis Nicole, DeFeo Anthony P, McElroy Amber N, Starker Colby G, Lee Catherine, Merkel Sarah, Lund Troy C, Kelly-Spratt Karen S, Jensen Michael C, Voytas Daniel F, von Kalle Christof, Schmidt Manfred, Gabriel Richard, Hippen Keli L, Miller Jeffrey S, Scharenberg Andrew M, Tolar Jakub, Blazar Bruce R

Abstract excerpt

Present adoptive immunotherapy strategies are based on the re-targeting of autologous T-cells to recognize tumor antigens. As T-cell properties may vary significantly between patients, this approach can result in significant variability in cell potency that may affect therapeutic outcome. More consistent results could be achieved by generating allogeneic cells from healthy donors. An impediment to such an...

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PMID: 26502778
DOI: 10.1038/mt.2015.197
PMCID: PMC4786913

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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