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Article

FOXO protects against age‐progressive axonal degeneration

26 Nov 2017

Abstract excerpt

Neurodegeneration resulting in cognitive and motor impairment is an inevitable consequence of aging. Little is known about the genetic regulation of this process despite its overriding importance in normal aging. Here, we identify the Forkhead Box O (FOXO) transcription factor 1, 3, and 4 isoforms as a guardian of neuronal integrity by inhibiting age-progressive axonal degeneration in mammals. FOXO expression...

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PMID: 29178390
DOI: 10.1111/acel.12701

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