Genetic dissection of murine susceptibilities to liver and lung tumors based on the two-stage concept of carcinogenesis.

Abstract excerpt

Inbred mouse strains exhibit strain-specific susceptibilities to spontaneous and induced tumors, indicating that the individual risks for neoplastic development are largely under genetic control. Recent advances in linkage analysis have made it routine to chromosomally map the mouse genes responsible for the strain variations in tumor susceptibility using segregating crosses. It is also possible to characterize...

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