Genetic dissection of murine susceptibilities to liver and lung tumors based on the two-stage concept of carcinogenesis.

doi:10.1111/j.1440-1827.1998.tb03863.x

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Article

Genetic dissection of murine susceptibilities to liver and lung tumors based on the two-stage concept of carcinogenesis.

Pathology international - 1 Dec 1998

Lee G H

Abstract excerpt

Inbred mouse strains exhibit strain-specific susceptibilities to spontaneous and induced tumors, indicating that the individual risks for neoplastic development are largely under genetic control. Recent advances in linkage analysis have made it routine to chromosomally map the mouse genes respons...

Topics

Animals
Carcinogens
Genetic Predisposition to Disease
Humans
Liver Neoplasms
Lung Neoplasms
Mice
Mice, Inbred Strains
Oncogenes

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