Article

A molecular circuit regulates fate plasticity in emerging and adult AT2 cells

2025-05-01

Abstract excerpt

Alveolar AT1 and AT2 cells are vital for lung gas exchange and become compromised in several diseases. While key differentiation signals are known, their emergence and fate plasticity are unclear. Here we show in the embryonic lung that single AT2s emerge at intermediate zones, extrude, and connect with nearby epithelium via interlumenal junctioning. We observe that AT2s retain fate plasticity until the bZIP trans...

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Literature Corpus work: 28970316-3848-5fa5-a6a3-3640b92b908f
DOI: 10.1101/2025.04.28.650846

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