Article

Release of Notch activity coordinated by IL-1β signalling confers differentiation plasticity of airway progenitors via Fosl2 during alveolar regeneration

2021-06-19

Abstract excerpt

While the acquisition of cellular plasticity in adult stem cells is essential for rapid regeneration after tissue injury, little is known about the underlying molecular mechanisms governing this process. Our data reveal the coordination of airway progenitor differentiation plasticity by inflammatory signals during alveolar regeneration. Upon damage, IL-1β signalling-dependent modulation of Jag1/2 expression in cil...

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Identifiers and source

Literature Corpus work: 99575869-a4da-5691-864d-9e7bba0f4da2
DOI: 10.1101/2021.06.19.449004

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