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PCLAF-DREAM drives alveolar cell plasticity for lung regeneration

24 Oct 2024

Abstract excerpt

Cell plasticity, changes in cell fate, is crucial for tissue regeneration. In the lung, failure of regeneration leads to diseases, including fibrosis. However, the mechanisms governing alveolar cell plasticity during lung repair remain elusive. We previously showed that PCLAF remodels the DREAM complex, shifting the balance from cell quiescence towards cell proliferation. Here, we find that PCLAF expression is...

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PMID: 39448571
DOI: 10.1038/s41467-024-53330-1

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