Article

Megakaryocyte NLRP3 hyperactivation induces anemia and potentiates inflammatory response in mice

2023-03-10

Abstract excerpt

<title>Abstract</title> <p>The NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome has been described in both immune cells and platelets but its role in the megakaryocyte (MK) lineage remains elusive. Here, we generated <italic>Nlrp3</italic><sup>A350V/+</sup>/<italic>Gp1ba</italic>-Cre<sup>KI/+</sup> mice carrying MK/platelet-specific mutation associated with human Muckle-Wells syndrome. Platel...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 28884922-c449-5f8b-82f1-7a5ae589a0a1
DOI: 10.21203/rs.3.rs-2616664/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Megakaryocyte NLRP3 hyperactivation induces anemia and potentiates inflammatory response in miceDOI 10.21203/rs.3.rs-2616664/v1Read

Platelets fuel the inflammasome activation of innate immune cellsSemantic proximity Read

Inflammasomes—New Contributors to Blood DiseasesSemantic proximity Read

The Role of Megakaryocytes in Myelofibrosis.Semantic proximity Read

Megakaryopoiesis and Platelet Biology: Roles of Transcription Factors and Emerging Clinical Implications.Semantic proximity Read

Single-cell analysis of ploidy and the transcriptome reveals functional and spatial divergency in murine megakaryopoiesisSemantic proximity Read

NLRP1 inflammasome activation induces pyroptosis of hematopoietic progenitor cells.Semantic proximity Read

Mpl expression on megakaryocytes and platelets is dispensable for thrombopoiesis but essential to prevent myeloproliferationSemantic proximity Read

Perforin and granzymes: function, dysfunction and human pathologySemantic proximity Read

Chronic TLR7 and TLR9 signaling drives anemia via differentiation of specialized hemophagocytesSemantic proximity Read

Transcription factors in megakaryocytes and plateletsSemantic proximity Read

Molecular mechanisms of megakaryopoiesisSemantic proximity Read

c-Mpl ligand is a humoral regulator of megakaryocytopoiesisSemantic proximity Read