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Transcription factors in megakaryocytes and platelets

9 Mar 2023

Abstract excerpt

Transcription factors bind promoter or regulatory sequences of a gene to regulate its rate of transcription. However, they are also detected in anucleated platelets. The transcription factors RUNX1, GATA1, STAT3, NFκB, and PPAR have been widely reported to play key roles in the pathophysiology of platelet hyper-reactivity, thrombosis, and atherosclerosis. These non-transcriptional activities are independent of...

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PMID: 36969155
DOI: 10.3389/fimmu.2023.1140501

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