Article
NLRP1 inflammasome activation induces pyroptosis of hematopoietic progenitor cells.
Immunity - 14 Dec 2012
Masters Seth L, Gerlic Motti, Metcalf Donald, Preston Simon, Pellegrini Marc, O'Donnell Joanne A, McArthur Kate, Baldwin Tracey M, Chevrier Stephane, Nowell Cameron J, Cengia Louise H, Henley Katya J, Collinge Janelle E, Kastner Daniel L, Feigenbaum Lionel, Hilton Douglas J, Alexander Warren S, Kile Benjamin T, Croker Ben A
Abstract excerpt
Cytopenias are key prognostic indicators of life-threatening infection, contributing to immunosuppression and mortality. Here we define a role for Caspase-1-dependent death, known as pyroptosis, in infection-induced cytopenias by studying inflammasome activation in hematopoietic progenitor cells. The NLRP1a inflammasome is expressed in hematopoietic progenitor cells and its activation triggers their pyroptotic...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.