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Article

The Role of Megakaryocytes in Myelofibrosis.

Hematology/oncology clinics of North America - 1 Apr 2021

Melo-Cardenas Johanna, Migliaccio Anna Rita, Crispino John D

Abstract excerpt

Megakaryocytes give rise to platelets, which have a wide variety of functions in coagulation, immune response, inflammation, and tissue repair. Dysregulation of megakaryocytes is a key feature of in the myeloproliferative neoplasms, especially myelofibrosis. Megakaryocytes are among the main drivers of myelofibrosis by promoting myeloproliferation and bone marrow fibrosis. In vivo targeting of megakaryocytes by...

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Identifiers

PMID: 33641863
DOI: 10.1016/j.hoc.2020.11.004
PMCID: PMC7921544

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