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Article

Multi-tissue epigenetic analysis of the osteoarthritis susceptibility locus mapping to the plectin gene <i>PLEC</i>

2020-01-28

Abstract excerpt

<h4>Objective</h4> Osteoarthritis (OA) associated single nucleotide polymorphism (SNP) rs11780978 correlates with differential expression of PLEC , and methylation quantitative trait loci (mQTLs) at PLEC CpGs in cartilage. This implies that methylation links chondrocyte genotype and phenotype, thus driving the functional effect. PLEC encodes plectin, a cytoskeletal protein that enables tissues to respond to me...

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Literature Corpus work
28737601-2a3f-55b3-ae7d-d7c6ef60bc4f
DOI
10.1101/2020.01.28.917401
Open publication

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Multi-tissue epigenetic analysis of the osteoarthritis susceptibility locus mapping to the plectin gene <i>PLEC</i>DOI 10.1101/2020.01.28.917401
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