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Article

An epigenome-wide view of osteoarthritis in primary tissues

8 Jun 2022

Abstract excerpt

Osteoarthritis is a complex degenerative joint disease. Here, we investigate matched genotype and methylation profiles of primary chondrocytes from macroscopically intact (low-grade) and degraded (high-grade) osteoarthritis cartilage and from synoviocytes collected from 98 osteoarthritis-affected individuals undergoing knee replacement surgery. We perform an epigenome-wide association study of knee cartilage...

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PMID: 35679866
DOI: 10.1016/j.ajhg.2022.05.010

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