Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Prioritization of PLEC and GRINA as Osteoarthritis Risk Genes Through the Identification and Characterization of Novel Methylation Quantitative Trait Loci

7 Feb 2019

Abstract excerpt

OBJECTIVE: To identify methylation quantitative trait loci (mQTLs) correlating with osteoarthritis (OA) risk alleles and to undertake mechanistic characterization as a means of target gene prioritization. METHODS: We used genome-wide genotyping and cartilage DNA methylation array data in a discovery screen of novel OA risk loci. This was followed by methylation, gene expression analysis, and genotyping studies in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Connective tissue disorders research
Share to Genetic Associations and Epidemiology
Share to Osteoarthritis Treatment and Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30730609
DOI: 10.1002/art.40849

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Prioritization of PLEC and GRINA as Osteoarthritis Risk Genes Through the Identification and Characterization of Novel Methylation Quantitative Trait LociPMID 30730609Read ↗

Multi-tissue epigenetic analysis of the osteoarthritis susceptibility locus mapping to the plectin gene <i>PLEC</i>Semantic proximity Read ↗

Multi-tissue epigenetic analysis of the osteoarthritis susceptibility locus mapping to the plectin gene PLEC.Semantic proximity Read ↗

Discovery and analysis of methylation quantitative trait loci (mQTLs) mapping to novel osteoarthritis genetic risk signalsSemantic proximity Read ↗

CRISPR-based epigenome and genome editing reveal novel roles for PLEC in cartilage biology, mechanobiology, and response to inflammationSemantic proximity Read ↗

Epigenetic analysis of Paget’s disease of bone identifies differentially methylated loci that predict disease statusSemantic proximity Read ↗

Integrative genomics establishes GNL3 as a pleiotropic hub and causal gene for osteoarthritis.Semantic proximity Read ↗

Allelic expression imbalance in articular cartilage and subchondral bone refined genome-wide association signals in osteoarthritis.Semantic proximity Read ↗

Integrative Genomics Establishes GNL3 as a Pleiotropic Hub and Causal Gene for OsteoarthritisSemantic proximity Read ↗

Integrative Omics Analysis of Rheumatoid Arthritis Identifies Non-Obvious Therapeutic TargetsSemantic proximity Read ↗

Functional characterisation of the osteoarthritis susceptibility locus at chromosome 6q14.1 marked by the polymorphism rs9350591.Semantic proximity Read ↗

The epigenomic landscape of primary tissues in osteoarthritis.Semantic proximity Read ↗

Allelic expression imbalance in articular cartilage and subchondral bone refined genome-wide association signals in osteoarthritisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.