Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ERAP1 overexpression in HPV-induced malignancies: A possible novel immune evasion mechanism

20 Jun 2017

Abstract excerpt

Immune evasion of tumors poses a major challenge for immunotherapy. For human papillomavirus (HPV)-induced malignancies, multiple immune evasion mechanisms have been described, including altered expression of antigen processing machinery (APM) components. These changes can directly influence epitope presentation and thus T-cell responses against tumor cells. To date, the APM had not been studied systematically in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cervical Cancer and HPV Research
Share to Colorectal and Anal Carcinomas
Share to Helicobacter pylori-related gastroenterology studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28811980
DOI: 10.1080/2162402x.2017.1336594

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ERAP1 overexpression in HPV-induced malignancies: A possible novel immune evasion mechanismPMID 28811980Read ↗

HPV Epitope Processing Differences Correlate with ERAP1 Allotype and Extent of CD8+ T-cell Tumor Infiltration in OPSCCSemantic proximity Read ↗

Immune evasion mechanisms of human papillomavirus: An updateSemantic proximity Read ↗

ERAP1: a potential therapeutic target for a myriad of diseasesSemantic proximity Read ↗

The Human Papillomavirus (HPV) E1 protein regulates the expression of cellular genes involved in immune responseSemantic proximity Read ↗

ERAP1 activity modulates the immunopeptidome but also affects the proteome, metabolism and stress responses in cancer cellsSemantic proximity Read ↗

Intracellular antigen processing by ERAP2: Molecular mechanism and roles in health and diseaseSemantic proximity Read ↗

Molecular backgrounds of ERAP1 downregulation in cervical carcinoma.Semantic proximity Read ↗

Critical role of endoplasmic reticulum aminopeptidase 1 in determining the length and sequence of peptides bound and presented by HLA-B27.Semantic proximity Read ↗

Naturally occurring ERAP1 haplotypes encode functionally distinct alleles with fine substrate specificity.Semantic proximity Read ↗

ERAP1 enzyme-mediated trimming and structural analyses of MHC I–bound precursor peptides yield novel insights into antigen processing and presentationSemantic proximity Read ↗

Autoimmune Disease-Associated Variants of Extracellular Endoplasmic Reticulum Aminopeptidase 1 Induce Altered Innate Immune Responses by Human Immune CellsSemantic proximity Read ↗

A Role for Naturally Occurring Alleles of Endoplasmic Reticulum Aminopeptidases in Tumor Immunity and Cancer Pre-DispositionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.