Article
Differences between disease-associated endoplasmic reticulum aminopeptidase 1 (ERAP1) isoforms in cellular expression, interactions with tumour necrosis factor receptor 1 (TNF-R1) and regulation by cytokines.
Clinical and experimental immunology - 1 May 2015
Yousaf N, Low W Y, Onipinla A, Mein C, Caulfield M, Munroe P B, Chernajovsky Y
Abstract excerpt
Endoplasmic reticulum aminopeptidase 1 (ERAP1) processes peptides for major histocompatibility complex (MHC) class I presentation and promotes cytokine receptor ectodomain shedding. These known functions of ERAP1 may explain its genetic association with several autoimmune inflammatory diseases. I...
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