Article

LF4/MOK and a CDK-related kinase regulate the number and length of cilia in <i>Tetrahymena</i>

2019-03-19

Abstract excerpt

The length of cilia is controlled by a poorly understood mechanism that involves members of the conserved RCK kinase group, and among them, the LF4/MOK kinases. In Tetrahymena , a loss of an LF4/MOK ortholog, LF4A, lengthened the locomotory cilia, but also reduced their total number per cell. Without LF4A, cilia assembled faster and showed signs of increased intraflagellar transport (IFT). Consistently, overprodu...

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Literature Corpus work: 286e90c3-f761-5d4d-8626-08731ed933c6
DOI: 10.1101/582833

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