Article
The kinases LF4 and CNK2 control ciliary length by feedback regulation of assembly and disassembly rates.
Current biology : CB - 18 Nov 2013
Hilton Laura K, Gunawardane Kavisha, Kim Joo Wan, Schwarz Marianne C, Quarmby Lynne M
Abstract excerpt
BACKGROUND: Many of the diverse functions of cilia depend upon tight control of their length. Steady-state length reflects a balance between rates of ciliary assembly and disassembly, two parameters likely controlled by a length sensor of unknown identity or mechanism. RESULTS: A null mutation in Chlamydomonas CNK2, a member of the evolutionarily conserved family of NIMA-related kinases, reveals feedback...
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