Article
CDKL5 regulates flagellar length and localizes to the base of the flagella in Chlamydomonas.
Molecular biology of the cell - 1 Mar 2013
Tam Lai-Wa, Ranum Paul T, Lefebvre Paul A
Abstract excerpt
The length of Chlamydomonas flagella is tightly regulated. Mutations in four genes-LF1, LF2, LF3, and LF4-cause cells to assemble flagella up to three times wild-type length. LF2 and LF4 encode protein kinases. Here we describe a new gene, LF5, in which null mutations cause cells to assemble flagella of excess length. The LF5 gene encodes a protein kinase very similar in sequence to the protein kinase CDKL5. In...
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