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Article

MRCK-1 activates non-muscle myosin for outgrowth of a unicellular tube in Caenorhabditis elegans.

Development (Cambridge, England) - 1 Dec 2024

Popiel Evelyn M, Ahluwalia Rhea, Schuetz Stefan, Yu Bin, Derry W Brent

Abstract excerpt

The formation and patterning of unicellular biological tubes is essential for metazoan development. It is well established that vascular tubes and neurons use similar guidance cues to direct their development, but the downstream mechanisms that promote the outgrowth of biological tubes are not well characterized. We show that the conserved kinase MRCK-1 and its substrate the regulatory light chain of non-muscle...

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PMID: 39494605
DOI: 10.1242/dev.202772
PMCID: PMC11634028

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