Article
Mutation of the MAP kinase DYF-5 affects docking and undocking of kinesin-2 motors and reduces their speed in the cilia of Caenorhabditis elegans.
Proceedings of the National Academy of Sciences of the United States of America - 24 Apr 2007
Burghoorn Jan, Dekkers Martijn P J, Rademakers Suzanne, de Jong Ton, Willemsen Rob, Jansen Gert
Abstract excerpt
In the cilia of the nematode Caenorhabditis elegans, anterograde intraflagellar transport (IFT) is mediated by two kinesin-2 complexes, kinesin II and OSM-3 kinesin. These complexes function together in the cilia middle segments, whereas OSM-3 alone mediates transport in the distal segments. Not much is known about the mechanisms that compartmentalize the kinesin-2 complexes or how transport by both kinesins is...
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