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Bearing variant alleles at uridine glucuronosyltransferase polymorphisms UGT2B7 -161C>T (rs7668258) or UGT1A4*3 c.142T>G (rs2011425) has no relevant consequences for lamotrigine troughs in adults with epilepsy

2022-11-29

Abstract excerpt

<h4>Purpose: </h4> . To estimate whether epilepsy patients with variant UGT2B7 -161C>T (rs7668258) or UGT1A4*3 c.142T>G (rs2011425) alleles differ from their wild-type (wt) peers in exposure to lamotrigine. <h4>Methods: </h4> . Consecutive adults on lamotrigine monotherapy or lamotrigine+valproate co-treatment undergoing routine therapeutic drug monitoring, otherwise generally healthy and free of interacting drug...

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Literature Corpus work
28686f41-ea06-5189-82d1-3e585cac545f
DOI
10.21203/rs.3.rs-2297781/v1
Open publication

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Bearing variant alleles at uridine glucuronosyltransferase polymorphisms UGT2B7 -161C&gt;T (rs7668258) or UGT1A4*3 c.142T&gt;G (rs2011425) has no relevant consequences for lamotrigine troughs in adults with epilepsyDOI 10.21203/rs.3.rs-2297781/v1
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